Prepare the roast: Pat the chuck roast dry with paper towels. Rub the roast with olive oil and season generously with garlic powder, onion powder, paprika, salt, and pepper. Optionally, add fresh herbs to the roast for extra flavor. Let the roast sit at room temperature for 15-20 minutes before cooking.
Preheat the air fryer: Set your air fryer to 375°F (190°C) and allow it to preheat for 5 minutes.
Cook the roast: Place the seasoned chuck roast in the air fryer basket. Cook for 50-60 minutes, flipping halfway through. Use a meat thermometer to check for doneness: 130°F (54°C) for medium-rare, 140°F (60°C) for medium, or 160°F (71°C) for well-done.
Rest the roast: Once cooked, remove the roast from the air fryer and let it rest for 10-15 minutes. This helps the juices redistribute for a more tender result.
Slice and serve: Slice the roast against the grain into thin slices and serve with your favorite side dishes.