Prep the shrimp: Pat the shrimp dry with paper towels. In a bowl, whisk together the flour, garlic powder, onion powder, paprika, salt, and pepper.
Batter the shrimp: In a separate bowl, whisk together the egg and buttermilk. Dip each shrimp into the buttermilk mixture, then coat with the flour mixture, ensuring they are evenly coated.
Fry the shrimp: Heat oil in a deep fryer or large pan to 350°F (175°C). Fry the shrimp in batches for 2-3 minutes or until golden brown and crispy. Remove and drain on paper towels.
Make the buffalo sauce: In a small saucepan, combine buffalo sauce, butter, and honey (if using). Heat over low heat until the butter is melted and the sauce is well-combined.
Toss the shrimp: Place the fried shrimp in a large bowl and pour the buffalo sauce over them. Toss to coat the shrimp evenly in the sauce.
Serve: Transfer the buffalo shrimp to a serving platter and garnish with fresh parsley, if desired. Serve immediately with celery sticks and blue cheese or ranch dressing for dipping.